High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles
Andreii S. Kritchenkov, Margarita N. Kurasova, Anastasia A. Godzishevskaya, Elizaveta S. Mitrofanova, Anton R. Egorov, Niyaz Z. Yagafarov, Moises J. Ballesteros Meza, Alexander G. Tskhovrebov, Alexey A. Artemjev, Elena V. Andrusenko, Victor N. Khrustalev
Abstract
The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin.