Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis
Yue Zhang, Wenhui Huang, Zemao Zheng, Wei Wang, Yafei Yuan, Qiaohui Hong, Jiajia Lin, Xu Li, Ying Meng
Topics & Concepts
AutophagyDNA damageNAD+ kinasePARP1SenescenceChemistryOxidative stressNicotinamide adenine dinucleotideMitophagyCell biologySirtuin 1Cancer researchBiologyMolecular biologyApoptosisPoly ADP ribose polymeraseBiochemistryDownregulation and upregulationDNAEnzymePolymeraseGeneInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisAutophagy in Disease and TherapyChronic Obstructive Pulmonary Disease (COPD) Research