Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity
Chen Chen, Hongrui Chu, Anyang Wang, Huanhuan Yin, Yanqiao Gao, Shuhua Liu, Wěi Li, Leiqiang Han
Topics & Concepts
ChemistryAcetylationHDAC1Histone deacetylaseLead compoundDNAWestern blotHistoneIC50Cell cultureStereochemistryBiochemistryMolecular biologyCancer researchIn vitroGeneticsBiologyGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsClick Chemistry and Applications