Clinical Evaluation of a Real-Time PCR Assay for Simultaneous Detection of Helicobacter pylori and Genotypic Markers of Clarithromycin Resistance Directly from Stool
Rebecca Marrero Rolón, Scott A. Cunningham, Jayawant N. Mandrekar, Erin T. Polo, Robin Patel
Abstract
Helicobacter pylori infection is mainly diagnosed noninvasively, with susceptibility testing traditionally requiring endoscopy. Treatment is empirical, with clarithromycin-based triple therapy recommended where resistance rates are below 15%. Rising rates of clarithromycin resistance, resulting in high therapy failure rates, are seen worldwide, but U.S. data are limited.
Topics & Concepts
ClarithromycinHelicobacter pyloriInternal medicineGenotypeGastroenterologyMedicineAntibiotic resistanceBiologyMicrobiologyAntibioticsGeneGeneticsHelicobacter pylori-related gastroenterology studiesVeterinary medicine and infectious diseasesGastric Cancer Management and Outcomes