Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 <sup>+</sup> T cells drive gastrointestinal acute graft-versus-host disease
Victor Tkachev, James J. Kaminski, E. Lake Potter, Scott N. Furlan, Alison Yu, Daniel J. Hunt, Connor McGuckin, Hengqi Zheng, Lucrezia Colonna, Ulrike Gerdemann, Judith Carlson, Michelle Hoffman, Joe Olvera, Chris English, Audrey Baldessari, Angela Panoskaltsis‐Mortari, Benjamin Watkins, Muna Qayed, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Amelia Langston, John Horan, José Ordovás-Montañés, Alex K. Shalek, Bruce R. Blazar, Mario Roederer, Leslie S. Kean
Abstract
Flow cytometric and transcriptomic analyses reveal coordinated tissue infiltration and tissue residence of donor T cells that drive gastrointestinal GVHD.
Topics & Concepts
Cytotoxic T cellCellCD8Graft-versus-host diseaseDiseaseImmunologyProfiling (computer programming)Gastrointestinal tractMedicineBiologyImmune systemPathologyInternal medicineGeneticsComputer scienceIn vitroOperating systemImmune Cell Function and InteractionImmune cells in cancerT-cell and B-cell Immunology