New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae
Dennis Nurjadi, Kaan Kocer, Quan Chanthalangsy, Sabrina Klein, Klaus Heeg, Sébastien Boutin
Abstract
evolution experiment using clinical E. cloacae isolates via serial passaging under cefiderocol pressure. In this study, we showed that the presence of the New Delhi metallo-β-lactamase (NDM) facilitates the emergence of resistance via nonsynonymous mutations of the CirA catecholate siderophore receptor. Inhibition of metallo-β-lactamase activity using dipicolinic acid prevented the emergence of cefiderocol-resistant mutants successfully. This finding implies that caution should be taken when using cefiderocol for the treatment of infections caused by metallo-β-lactamase-producing bacteria.
Topics & Concepts
SiderophoreBiologyEnterobacter cloacaeBacilliCephalosporinMicrobiologyNew delhiEnterobacterResistance (ecology)BiotechnologyBacteriaAntibiotic resistanceMutantAntibiotic Resistance in BacteriaAntimicrobial agents and applicationsNosocomial Infections in ICU