Aspermeroterpenes A–C: Three Meroterpenoids from the Marine-Derived Fungus <i>Aspergillus terreus</i> GZU-31-1
Yuqian Tang, Yena Liu, Qingfeng Ruan, Min Zhao, Zhongxiang Zhao, Hui Cui
Abstract
Aspermeroterpene A (1) with an unprecedented and highly congested 5/3/6/6/6/5 hexacyclic skeleton, together with two precursors aspermeroterpenes B (2) and C (3), were isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Their structures were elucidated by quantum chemical calculations, X-ray diffraction, and spectroscopic methods. The biogenetic pathway for 1–3 is proposed. Aspermeroterpenes A–C (1–3) showed significant inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells compared to positive control.
Topics & Concepts
Aspergillus terreusChemistryFungusStereochemistryNitric oxideQuantum chemicalMoleculeOrganic chemistryBiochemistryBotanyBiologyMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsFungal Biology and Applications