Ferrous ions doped layered double hydroxide: smart 2D nanotheranostic platform with imaging-guided synergistic chemo/photothermal therapy for breast cancer
Zhenhu Guo, Wensheng Xie, Jingsong Lu, Xiaoxiao Guo, Yongjie Chi, Dan Wang, Nonaka Takuya, Wanling Xu, Jielin Ye, Xiangyan Liu, Zi Gu, Benhua Xu, Hong Wu, Lingyun Zhao
Abstract
-weighted MRI effect revealed that the as-prepared Fe-LDH/DOX is sensitive to the tumor acid microenvironment. Most importantly, the growth rate of tumors in 4T1 bearing mice could be effectively inhibited after the synergistic treatment of PTT and chemotherapy by Fe-LDH/DOX. These results show that doping functional metal ions into LDH NPs may open a novel approach to fabricating an LDH NP-based nanotheranostics platform with advanced diagnostic and therapeutic performances.
Topics & Concepts
Photothermal therapyHydroxideFerrousChemistryDopingBreast cancerIonCancerNanotechnologyInorganic chemistryMaterials scienceInternal medicineOptoelectronicsMedicineOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Photocatalysis TechniquesGa2O3 and related materials