A GPX4-targeted photosensitizer to reverse hypoxia-induced inhibition of ferroptosis for non-small cell lung cancer therapy
Qiao Hu, Wanjie Zhu, Jianjun Du, Haoying Ge, Jiazhu Zheng, Saran Long, Jiangli Fan, Xiaojun Peng
Abstract
A GPX4 targeted photosensitizer ENBS-ML210 was prepared to promote lipid peroxidation, which reversed the hypoxia-induced resistance of ferroptosis for non-small cell lung cancer therapy.
Topics & Concepts
GPX4PhotosensitizerCancer researchPhotodynamic therapyLipid peroxidationHypoxia (environmental)Lung cancerChemistrySuperoxideIn vivoTumor microenvironmentGlutathioneGlutathione peroxidaseOxidative stressMedicineBiochemistryBiologyOxygenTumor cellsEnzymeInternal medicinePhotochemistryOrganic chemistryBiotechnologyFerroptosis and cancer prognosisNanoplatforms for cancer theranosticsCancer, Hypoxia, and Metabolism