A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis
Chengui Lu, Changjiang Guo, Han Chen, Huiyong Zhang, Lingtong Zhi, Tanyu Lv, Mingfeng Li, Zhiyuan Niu, Ping Lu, Wuling Zhu
Topics & Concepts
Cancer researchPyroptosisNKG2DLung cancerChimeric antigen receptorChemistryMedicinePharmacologyReceptorCytotoxicityCancerImmunotherapyOncologyInternal medicineBiochemistryIn vitroInflammasomeImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersInflammasome and immune disorders