A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams <i>via</i> palladium-catalyzed carbonylation
Yang Li, Cai‐Lin Zhang, Weiheng Huang, Ning Sun, Meng Hao, Helfried Neumann, Matthias Beller
Abstract
β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields.
Topics & Concepts
CarbonylationPalladiumTrifluoromethylCatalysisChemistryCombinatorial chemistryOrganic chemistryCarbon monoxideAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Reactions of Organic Compounds