Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
Ornella I. Selmin, Micah G. Donovan, Barbara Stillwater, Leigh Neumayer, Donato F. Romagnolo
Abstract
Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.
Topics & Concepts
Triple-negative breast cancerBreast cancerEpigeneticsEstrogen receptorEpidermal growth factor receptorCancer researchMetastasisEstrogenOncologyCancerInternal medicineMedicineBiologyBioinformaticsGeneticsGeneEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchMetabolism, Diabetes, and Cancer