Histidine-rich glycoprotein possesses antioxidant activity through self-oxidation and inhibition of hydroxyl radical production via chelating divalent metal ions in Fenton’s reaction
Hidenori Wake, Yohei Takahashi, Yukinori Yoshii, Shangze Gao, Shuji Mori, Dengli Wang, Kiyoshi Teshigawara, Masahiro Nishibori
Abstract
and that HRG could be potential therapy for ROS-related diseases.
Topics & Concepts
Hydroxyl radicalChemistryAntioxidantReactive oxygen speciesSuperoxide dismutaseRadicalCatalasePro-oxidantOxidative stressDivalentBiochemistryGlutathioneEnzymeOrganic chemistrySepsis Diagnosis and TreatmentS100 Proteins and AnnexinsImmune Response and Inflammation