Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation
Kotaro Sugawara, Miwako Iwai, Hirotaka Ito, Minoru Tanaka, Yasuyuki Seto, Tomoki Todo
Abstract
T cells were required for synergistic curative activity. The results depict the dynamics of immune modulation of the tumor microenvironment and provide a clinical rationale for using G47Δ with immune checkpoint inhibitors.
Topics & Concepts
Oncolytic virusImmune systemTumor microenvironmentAntibodyCytotoxic T cellImmunogenicityCancer researchImmune checkpointImmunotherapyBiologyImmunologyMedicineIn vitroBiochemistryVirus-based gene therapy researchCAR-T cell therapy researchHerpesvirus Infections and Treatments