Insight into Vaccine Development for Alphacoronaviruses Based on Structural and Immunological Analyses of Spike Proteins
Yuejun Shi, Jiale Shi, Limeng Sun, Yubei Tan, Gang Wang, Fenglin Guo, Guangli Hu, Yanan Fu, Zhen F. Fu, Shaobo Xiao, Guiqing Peng
Abstract
(HCoV-229E) with a RBD "lying" state, the S-trimer may be more suitable for subunit vaccines than the RBD. Our results will provide novel ideas for the development of vaccines targeting S protein in the future.
Topics & Concepts
TrimerCoronavirusVirologyAntibodyBiologyTiterNeutralizing antibodyAntibody titerProtein subunitSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirusCoronavirus disease 2019 (COVID-19)ChemistryImmunologyGeneticsMedicineGeneOrganic chemistryInfectious disease (medical specialty)DiseaseDimerPathologySARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology