Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study
Il Heon Ha, Changmok Lim, Yeahoon Kim, Yeonsil Moon, Seol‐Heui Han, Won‐Jin Moon
Abstract
OBJECTIVE: This study aimed to determine whether there are regional differences in the blood-brain barrier (BBB) permeability of cognitively normal elderly participants and to identify factors influencing BBB permeability with a clinically feasible, 10-minute dynamic contrast-enhanced (DCE) MRI protocol. MATERIALS AND METHODS: and the factors of age, sex, education, cognition score, vascular risk burden, vascular factors on imaging, and medial temporal lobar atrophy were assessed using Pearson correlation and the Spearman rank test. RESULTS: across brain regions were not related to age, cognitive score, vascular risk burden, vascular risk factors on imaging, or medial temporal lobar atrophy in the study group. CONCLUSION: values when evaluating BBB permeability in patients with neurodegenerative diseases.