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2′-Fucosyllactose alleviates OVA-induced food allergy in mice by ameliorating intestinal microecology and regulating the imbalance of Th2/Th1 proportion

Ruixin Kou, Jin Wang, Ang Li, Yuanyifei Wang, Dancai Fan, Bowei Zhang, Wenhui Fu, Jingmin Liu, Hanyue Fu, Shuo Wang

2023Food & Function28 citationsDOIOpen Access PDF

Abstract

. Additionally, 2'-FL ameliorated the imbalance of Th2/Th1, mainly by decreasing Th2-type immune response and enhanced CD4 + Foxp3 + Treg immunoreaction. These results suggest that 2'-FL restores intestinal barrier defects, gut microbiota disorder, and immune impairment while alleviating ovalbumin-induced allergic symptoms in FA mice.

Topics & Concepts

MicroecologyAllergyFood allergyImmunologyBiologyMedicineMicrobiologyFood Allergy and Anaphylaxis ResearchEosinophilic EsophagitisAsthma and respiratory diseases
2′-Fucosyllactose alleviates OVA-induced food allergy in mice by ameliorating intestinal microecology and regulating the imbalance of Th2/Th1 proportion | Litcius