Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study
Martin Krátký, Quynh Anh Vu, Šárka Štěpánková, Annalisa Maruca, Tiago Silva, Martin Ambrož, Václav Pflégr, Roberta Rocca, Katarína Svrčková, Stefano Alcaro, Fernanda Borges, Jarmila Vinšová
Topics & Concepts
ChemistryButyrylcholinesteraseStereochemistryPharmacophoreDocking (animal)Monoamine neurotransmitterEnzymeCholinesteraseAcetylcholinesteraseMonoamine oxidaseIC50CarbamateIn vitroCombinatorial chemistryAchéBiochemistryPharmacologySerotoninReceptorMedicineNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsMedicinal Plants and Neuroprotection