Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold
Tulika Anthwal, Sarvesh Paliwal, Sumitra Nain
Abstract
The chemistry of 1,3,4-thiadiazole is one of the most interesting scaffolds for synthesizing new drug molecules due to their numerous pharmacological activities. Several modifications in the thiadiazole ring have been made, proving it to be more potent and highly effective with a less toxic scaffold for various biological activities. There are several marketed drugs containing 1,3,4-thiadiazole ring in their structure. In this review article, we have tried to compile the newly synthesized 1,3,4-thiadiazole derivatives possessing important pharmaceutical significance since 2014.
Topics & Concepts
ScaffoldChemistryCombinatorial chemistryRing (chemistry)Drug discoveryNanotechnologyMaterials scienceBiochemistryOrganic chemistryMedicineBiomedical engineeringSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation