Mechanistic dichotomy in the solvent dependent access to <i>E vs. Z</i>-allylic amines <i>via</i> decarboxylative vinylation of amino acids
Samir Manna, Shunta Kakumachi, Kanak Kanti Das, Youichi Tsuchiya, Chihaya Adachi, Santanu Panda
Abstract
A solvent-dependent access to E vs. Z -allylic amines was achieved via decarboxylative vinylation of amino acids. Detailed experimental studies have been conducted to understand the role of the solvent in the reactivity and stereoselectivity of the vinylation reactions.
Topics & Concepts
Allylic rearrangementStereoselectivityChemistrySolventReactivity (psychology)DecarboxylationAmino acidOrganic chemistrySolvent effectsCombinatorial chemistryMedicinal chemistryCatalysisBiochemistryPathologyMedicineAlternative medicineRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods