Cerebral and splanchnic oxygenation during automated control of inspired oxygen (FiO<sub>2</sub>) in preterm infants
Carlo Dani, Simone Pratesi, Michele Luzzati, Chiara Petrolini, Simona Montano, Giulia Remaschi, Caterina Coviello
Abstract
Abstract Objectives Our aim in this study was to assess the effect of the Predictive Intelligent Control of Oxygenation (PRICO ® ) system on cerebral (rSO 2 C) and splanchnic (rSO 2 S) oxygenation in a cohort of preterm infants with frequent desaturations. Methods Twenty infants with gestational age <32 weeks ( n = 20) were assigned in random sequence to 12 h of automated or manual adjustment of FiO 2 . Over this period, they were studied continuously by near‐infrared spectroscopy (NIRS). Results We found that rSO 2 C [68.0% (60.5%–74.7%) vs. 68.5% (62%–72%); p = .824] and rSO 2 S [27.0% (17.3%–45.7%) vs. 27.0% (15%–53%); p = .878] were similar during automatic and manual control of FiO 2 . Time spent with SpO 2 90%–95% was higher during the automatic than manual control of FiO 2 , while time spent with SpO 2 <80% or >95% was lower. Conclusions Automated control of FiO 2 with PRICO ® system did not improve brain and splanchnic oxygenation in comparison with manual control in a cohort of preterm infants, but it significantly decreased SpO 2 fluctuations and limited the duration of both hypoxemia and hyperoxemia.