Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria
Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia
Abstract
There is an urgent need to clearly understand the mechanisms of ART resistance as it is emerging in the Greater Mekong Subregion (GMS) and other parts of the world, such as Africa. Deciphering the mechanisms of the parasite's stress response pathways of ART resistance will provide insights to identify novel drug targets for developing new antimalarial regimens.
Topics & Concepts
ProteostasisArtemisininMalariaAutophagyPlasmodium falciparumDrug resistanceVirologyBiologyMedicineImmunologyMicrobiologyCell biologyBiochemistryApoptosisMalaria Research and ControlMosquito-borne diseases and controlAutophagy in Disease and Therapy