Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of <i>N</i>-(2-iodo-aryl) acrylamide
Guangzhu Wang, Chaoren Shen, Xinyi Ren, Kaiwu Dong
Abstract
-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.
Topics & Concepts
CyanationChemistryArylEnantioselective synthesisAcrylamideCatalysisAlkeneElectrophileMedicinal chemistryReagentCyanideIntramolecular forceCombinatorial chemistryOrganic chemistryAlkylCopolymerPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAlkaloids: synthesis and pharmacology