Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade
Fei Shao, Yibo Gao, Wei Wang, Haiyan He, Liwei Xiao, Xiao Geng, Yan Xia, Dong Guo, Jing‐Yuan Fang, Jie He, Zhimin Lu
Topics & Concepts
CD59Cancer researchImmune checkpointDownregulation and upregulationImmune systemBiologyComplement systemCD8Wnt signaling pathwayImmunotherapyImmunologyCell biologySignal transductionBiochemistryGeneComplement system in diseasesCancer-related molecular mechanisms researchImmune Cell Function and Interaction