Identification of a novel microRNA-141-3p/Forkhead box C1/β-catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro
Jun Wang, Yin Wang, Hui Zhang, Jun Chang, Ming Lu, Weilu Gao, Wendong Liu, Yetian Li, Li Yin, Xiaohe Wang, Yuejun Wang, Mengru Gao, Zongsheng Yin
Abstract
: FoxC1 and miR-141-3p participate in RA pathogenesis by mediating inflammation and SF proliferation, migration, and invasion and thus could be novel targets for RA therapy as a nonimmunosuppressive approach.
Topics & Concepts
Gene knockdownCyclin D1Gene silencingDownregulation and upregulationWnt signaling pathwayCancer researchBlotMolecular biologyBiologyCell biologySignal transductionCell cycleCell cultureCellGeneBiochemistryGeneticsSignaling Pathways in DiseaseBone Metabolism and DiseasesCytokine Signaling Pathways and Interactions