Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway
Hanan A. Ogaly, Rehab F. Abdel‐Rahman, Marawan A. Elbaset, Ahmed-Farid O.A., Marwa S. Khattab, Reham M. Abd‐Elsalam
Abstract
THY was found to exert hepato- and neuroprotective effects against HE via its antioxidant, anti-inflammatory effects in addition to activation of the CREB/BDNF signaling pathway.
Topics & Concepts
ThioacetamideCREBNeurotoxicityNeuroprotectionHepatic encephalopathyEndocrinologyPharmacologyOxidative stressAstrocyteInternal medicineChemistryMorris water navigation taskMedicineHippocampusToxicityCentral nervous systemBiochemistryTranscription factorCirrhosisGeneLiver Disease and TransplantationDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology