Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan
Anagh Pathak, Vivek Sharma, Dipanjan Roy, Arpan Banerjee
Abstract
We propose that the preservation of functional integration, estimated from measures of neural synchrony, is a key objective of neurocompensatory mechanisms associated with healthy human ageing. To support this proposal, we demonstrate how phase-locking at the peak alpha frequency in Magnetoencephalography recordings remains invariant over the lifespan in a large cohort of human participants, aged 18-88 years. Using empirically derived connection topologies from diffusion tensor imaging data, we create an in-silico model of whole-brain alpha dynamics. We show that enhancing inter-areal coupling can cancel the effect of increased axonal transmission delays associated with age-related degeneration of white matter tracts, albeit at slower network frequencies. By deriving analytical solutions for simplified connection topologies, we further establish the theoretical principles underlying compensatory network re-organization. Our findings suggest that frequency slowing with age- frequently observed in the alpha band in diverse populations- may be viewed as an epiphenomenon of the underlying compensatory mechanism.