Recent Advances in Application of Circularly Polarized Luminescence Probes toward Bioimaging Technology
Dong Li, Zhenhao Jiang, Xinyu Liu, Yixiang Cheng
Abstract
High Resolution Image Download MS PowerPoint Slide Circularly polarized luminescence (CPL) refers to the differential emission of left- and right-handed circularly polarized light in chiral materials, exhibiting significant potential for applications in bioimaging. The introduction of CPL can effectively eliminate the background autofluorescence interference, thereby enhancing the signal-to-noise ratio and resolution. Furthermore, CPL probes serve as robust detection tools capable of directly identifying the unique optical fingerprint information on the chiral targets, enabling real-time dynamic tracking of species within organisms, thus facilitating higher-dimensional bioimaging. Recently, a new series of CPL probes has been developed for cellular and in vivo imaging. This review summarizes the research progress of various CPL probes designed for efficient bioimaging, including CPL-active lanthanide metal complexes, small molecules, and nanomaterials. Finally, we discuss the current challenges and future prospects of these CPL probes in the field of bioimaging.