Molybdenum‐Catalyzed Deoxygenative Cyclization of Carbonyl Compounds for the Synthesis of Pyrido[2,1‐<i>a</i>]isoindoles
Sobi Asako, Takafumi Kobayashi, Seina Ishihara, Kazuhiko Takai
Abstract
Abstract A simple catalytic system consisting of Mo(0) and ortho‐quinone as catalyst and phosphine as a reductant has been developed for the synthesis of pyridoisoindoles and pyridoisoindolium salts through the deoxygenation of carbonyl compounds.
Topics & Concepts
ChemistryDeoxygenationCatalysisPhosphineMolybdenumQuinoneOrganic chemistryCombinatorial chemistryMedicinal chemistrySynthesis and Reactivity of HeterocyclesSynthesis and pharmacology of benzodiazepine derivativesCoordination Chemistry and Organometallics