Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure
Yulong Wu, Zhou-Yan Dong, Xinze Jiang, Lei Qu, Wei Zhou, Xu Sun, Jiangshan Hou, Hongmei Xu, Mei Cheng
Abstract
Our study indicated that the gut microbiota contributes to spatial learning and memory dysfunction after chronic METH exposure, in which microglial phenotype status plays an intermediary role. The elucidated "specific microbiota taxa-microglial M1/M2 phenotypes-spatial learning and memory impairment" pathway would provide a novel mechanism and elucidate potential gut microbiota taxon targets for the no-drug treatment of cognitive deterioration after chronic METH exposure.
Topics & Concepts
Meth-Gut floraBiologyMethamphetamineMicrogliaNeurosciencePhenotypeHippocampal formationBrain-derived neurotrophic factorNeurotrophic factorsImmunologyInflammationReceptorGeneticsPharmacologyChemistryOrganic chemistryMonomerGenePolymerAcrylateGut microbiota and healthNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders