FSO<sub>2</sub> Radical-Initiated Tandem Addition Reaction of Two Different Olefins: A Facile Access to Multifunctional Aliphatic Sulfonyl Fluorides
Na Yang, Chenxi Mao, Honghai Zhang, Peng Wang, Shaojie Li, Lili Xie, Saihu Liao
Abstract
Multicomponent reactions represent a powerful method for building complex molecules from structurally simple starting materials. Herein, we report a novel three-component radical-polar crossover reaction involving a tandem addition reaction of two different olefins, which is initiated by the selective addition of fluorosulfonyl radicals to alkyl alkenes. This tandem process provides facile and effective access to multiple functionalized aliphatic sulfonyl fluoride molecules. Further transformation of the products is also demonstrated.
Topics & Concepts
ChemistrySulfonylTandemAlkylRadicalMoleculeCascade reactionFluorideCombinatorial chemistryOrganic chemistryPhotochemistryCatalysisInorganic chemistryComposite materialMaterials scienceSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods