Advances in the Structural Biology, Mechanism, and Physiology of Cyclopropane Fatty Acid Modifications of Bacterial Membranes
John E. Cronan, Tiit Luk
Abstract
Cyclopropane fatty acid (CFA) synthase catalyzes a remarkable reaction. The cis double bonds of unsaturated fatty acyl chains of phospholipid bilayers are converted to cyclopropane rings by transfer of a methylene moiety from S-adenosyl-L-methionine (SAM).
Topics & Concepts
CyclopropanePhospholipidMoietyBiologyFatty acidMembraneMethyleneLipid bilayerBiochemistryUnsaturated fatty acidStereochemistryOrganic chemistryChemistryRing (chemistry)RNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyEnzyme Structure and Function