Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance
Milena Kordalewska, Geselle Cancino-Prado, João Nóbrega de Almeida, Igor Brasil Brandão, Renata Tigulini de Souza Peral, Arnaldo Lopes Colombo, David S. Perlin
Abstract
We determined the echinocandin susceptibility and FKS1 genotypes of 13 clinical isolates of Candida auris that were recovered from 4 patients at a tertiary care center in Salvador, Brazil. Three isolates were categorized as echinocandin-resistant, and they harbored a novel FKS1 mutation that led to an amino acid change W691L located downstream from hot spot 1.
Topics & Concepts
EchinocandinAnidulafunginCandida aurisMicafunginEchinocandinsMicrobiologyCaspofunginInvasive candidiasisBiologyCandida glabrataMedicineAntifungalVoriconazoleFluconazoleAntifungal resistance and susceptibilityFungal Infections and StudiesNematode management and characterization studies