A novel stress-inducible CmtR-ESX3-Zn2+ regulatory pathway essential for survival of Mycobacterium bovis under oxidative stress
Xiaohui Li, Liu Chen, Jingjing Liao, Jiechen Hui, Weihui Li, Zheng‐Guo He
Abstract
transportation that has been reported earlier, and inhibit phagosome maturation in macrophages. Lastly, CmtR significantly contributes to bacterial survival in macrophages and in the lungs of infected mice. Our findings reveal the existence of an antioxidant regulatory pathway in mycobacteria and provide novel information on stress-triggered gene regulation and its association with host-pathogen interaction.
Topics & Concepts
Oxidative stressMycobacterium bovisMicrobiologyOxidative phosphorylationChemistryBiologyCell biologyMycobacterium tuberculosisBiochemistryMedicineTuberculosisPathologyMycobacterium research and diagnosisNeutrophil, Myeloperoxidase and Oxidative MechanismsLegionella and Acanthamoeba research