<i>APOE ϵ</i> 4 modifies the relationship between infectious burden and poor cognition
Chen Zhao, Kevin Strobino, Yeseon Park Moon, Ying Kuen Cheung, Ralph L. Sacco, Yaakov Stern, Mitchell S.V. Elkind
Abstract
OBJECTIVE: is an effect modifier of the association between infectious burden (IB) and poor cognition in a multiethnic cohort, the Northern Manhattan Study. METHODS: and IBI. RESULTS: 4 carriers (β = 0.27, 95% CI -0.09 to 0.64). CONCLUSIONS: 4 allele on the relationship of infection, and particularly viral infection, to cognitive processing speed warrants further investigation.
Topics & Concepts
Confidence intervalApolipoprotein EMedicineLogistic regressionCognitionMulticenter AIDS Cohort StudyInternal medicineNeuropsychologyMini–Mental State ExaminationNeuropsychological testImmunologyPsychiatryViral loadHuman immunodeficiency virus (HIV)DiseaseCognitive impairmentAntiretroviral therapyInfectious Encephalopathies and EncephalitisLong-Term Effects of COVID-19Health, Environment, Cognitive Aging