Marine actinomycetes-derived angucyclines and angucyclinones with biosynthesis and activity--past 10 years (2014–2023)
Xiao Xu, Xiaofei Huang, Wenhua Xu
Abstract
Actinomycete bacteria derived from marine environments are a good source of natural products with diverse biological activities such as cytotoxicity, antiviral, and antimicrobial actions. This review summarizes 191 angucyclines and angucyclinones derived from marine actinomycetes reported in the literature from 2014 to 2023 and introduced the latest developments in actinomycete-silenced biosynthetic gene cluster activation, including heterologous recombination and in situ activation. The key role of redox post-modifications in the biosynthetic process of atypical angucyclines. This review provides insights into the discovery and biosynthesis of valuable angucyclines and angucyclinones from marine-associated actinomycetes and potential lead compounds for the research and development of new drugs. • Marine actinomycetes evolved unique survival mechanisms in extreme marine environments and can produce a variety of bioactive substances. • Angucyclines are a large family of polycyclic aromatic polyketides with a broad range of biological activities • 191 angucyclines and angucyclinones derived from marine actinomycetes reported in the literature from 2014 to 2023 and introduced the latest developments in actinomycete-silenced BGC activation, including heterologous recombination and in situ activation. • The key role of redox post-modifications in the biosynthetic process of atypical angucyclines.