Tumor Acid Microenvironment-Triggered Self-Assembly of ESIONPs for T<sub>1</sub>/T<sub>2</sub> Switchable Magnetic Resonance Imaging
Yilin He, Mao Zheng, Ye Zhang, Haiyin Lv, Jincong Yan, Yi Cao, Renjun Pei
Abstract
contrasting effect, which can be employed to realize the selective enhancement of imaging contrast at the tumor location owing to the weakly acid microenvironment. Moreover, on the basis of size increase originated from the aggregation effect, the residence time of extremely small iron oxide nanoparticles (ESIONPs) in the tumor site is effectively prolonged, which is beneficial for the MRI of tumors. Therefore, the pH-responsive system based on the ESIONPs is a potential smart MRI contrast agent for accurate tumor diagnosis.
Topics & Concepts
Magnetic resonance imagingPEG ratioChemistryTumor microenvironmentNanoparticleBiophysicsGadoliniumNuclear magnetic resonanceMaterials scienceNanotechnologyTumor cellsCancer researchOrganic chemistryMedicineFinanceRadiologyEconomicsPhysicsBiologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryLanthanide and Transition Metal Complexes