Synthesis and photodynamic activities of novel silicon(<scp>iv</scp>) phthalocyanines axially substituted with water soluble groups against HeLa cancer cell line
Meltem Göksel, Mahmut Durmuş, Zekeriya Bıyıklıoğlu
Abstract
C-NMR and UV-vis as well as mass spectroscopy. The photophysicochemical properties (fluorescence quantum yields and lifetimes, singlet oxygen, and photodegradation quantum yields) were investigated in DMSO for all the studied SiPcs (3 and 4) and in both DMSO and aqueous solutions for the water soluble SiPcs (3a and 4a). Effects of quaternization of these phthalocyanines on photophysicochemical properties were also determined. The photodynamic therapy activities of the water soluble SiPcs (3a and 4a) were tested against to the HeLa cancer cell lines and these phthalocyanines exhibited cytotoxicity against these cell lines.
Topics & Concepts
HeLaAxial symmetrySiliconCancer cell linesPhotodynamic therapyChemistryCell cultureLine (geometry)PhthalocyanineCombinatorial chemistryCancer cellCancerCellPhotochemistryMaterials scienceNanotechnologyOrganic chemistryBiochemistryPhysicsBiologyGeometryQuantum mechanicsMathematicsGeneticsPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research StudiesPhotosynthetic Processes and Mechanisms