Impact of weight loss and partial weight regain on immune cell and inflammatory markers in adipose tissue in male mice
Alexander T. Sougiannis, Brandon N. VanderVeen, Taryn L. Cranford, Reilly T. Enos, Kandy T. Velázquez, Sierra J. McDonald, Jackie E. Bader, Ioulia Chatzistamou, Daping Fan, E. Angela Murphy
Abstract
We examined the immune and inflammatory status of adipose tissue in mice after they underwent weight loss followed by partial weight regain. We show an increase in selected immune cells and inflammatory mediators, in high-fat diet-fed mice that had prior exposure to a high-fat diet. Although weight fluctuations appear to exacerbate immune cell abundance and inflammation in adipose tissue, severity is less than in mice that were exposed to sustained high-fat diet feedings.
Topics & Concepts
Adipose tissueImmune systemInflammationWeight lossEndocrinologyInternal medicineBiologyObesityMedicineImmunologyAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity