Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve
Elisabeth DiNello, Elisa Bovo, Paula Thuo, Thomas G. Martin, Jonathan A. Kirk, Aleksey V. Zima, Quan Cao, Ivana Y. Kuo
Abstract
Our goal was to characterize the role of the transient receptor potential channel polycystin 2 (PC2) in cardiomyocytes following adult-onset deletion. Loss of PC2 resulted in decreased cardiac shortening and cardiac dyssynchrony and diminished adrenergic reserve. These results suggest that cardiac-specific PC2 modulates intracellular calcium signaling and contributes to the maintenance of adrenergic pathways.
Topics & Concepts
Ryanodine receptorInternal medicineEndocrinologyCalciumCalcium in biologyChemistryVoltage-dependent calcium channelAdrenergic receptorRyanodine receptor 2ReceptorBiologyMedicineMarine Toxins and Detection MethodsIon channel regulation and functionNonlinear Dynamics and Pattern Formation