MicroRNA-211 Modulates the DUSP6-ERK5 Signaling Axis to Promote BRAFV600E-Driven Melanoma Growth In Vivo and BRAF/MEK Inhibitor Resistance
Bongyong Lee, Anupama Sahoo, Junko Sawada, John Marchica, Sanjay Sahoo, Fabiana Izidro Layng, Darren Finlay, Joseph Mazar, Piyush Joshi, Masanobu Komatsu, Kristiina Vuori, Petrus R. de Jong, Animesh Ray, Ranjan J. Perera
Topics & Concepts
VemurafenibMAPK/ERK pathwayMelanomaCancer researchKinaseCell growthMEK inhibitorBiologymicroRNADUSP6Signal transductionCell biologyPhosphorylationPhosphataseGeneticsGeneProtein phosphatase 2Metastatic melanomaMelanoma and MAPK PathwaysProtein Tyrosine Phosphatasesinterferon and immune responses