Enantioselective Synthesis of δ-Carbolinones via N-Heterocyclic Carbene Catalysis
Simiao Zhang, Lin Chen, Chaolei Liu, Ding Du
Abstract
An enantioselective synthesis of δ-carbolinones was accomplished through N-heterocyclic carbene-catalyzed formal [3+3] annulation of 3-aminoindoles with 2-bromoenals. This protocol offers a rapid and efficient synthetic approach for accessing a wide range of enantioenriched structurally interesting δ-carbolinones under mild reaction conditions.
Topics & Concepts
Enantioselective synthesisChemistryCarbeneAnnulationCatalysisCombinatorial chemistryOrganocatalysisOrganic chemistryStereochemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods