Visible Light Photocatalytic Trifluoromethylation/SET Oxidation/Cycloaddition Sequences of 2‐Vinyl Phenols: Multicomponent Synthesis of 4<i>H</i>‐Chromenes
Ji‐Hoon Jang, Dae Young Kim
Abstract
Abstract Visible light‐mediated photocatalytic trifluoromethylation, single electron transfer (SET) oxidation, and cycloaddition cascades of 2‐vinyl phenols with Umemoto's reagent and malononitrile were developed. This approach provided the multicomponent synthesis of trifluoromethylated 4 H ‐chromenes via the in situ generation of o ‐quinone methides, followed by sequential cyclization.
Topics & Concepts
TrifluoromethylationChemistryReagentCycloadditionPhotocatalysisMalononitrilePhenolsVisible spectrumPhotochemistryQuinoneResorcinolOrganic chemistryCombinatorial chemistryCatalysisOptoelectronicsAlkylPhysicsTrifluoromethylFluorine in Organic ChemistrySynthesis of Indole DerivativesRadical Photochemical Reactions