Recent Advances in Electrochemical C(3)—H Functionalization of Quinoxalin-2(1<i>H</i>)-ones
Dandan Li, Xiaochen Wang, Shanshan Li, Chenyu Fu, Qianqian Li, Dongtao Xu, Yingying Ma
Abstract
Quinoxalinone and its derivatives are a class of important nitrogen heterocyclic compounds, which widely exist in natural products, drugs and functional materials. Therefore, the C-H functionalization of quinoxalinone has attracted extensive attention of chemical workers. In recent years, electrochemical synthesis directly uses electron as a "clean reagent" to participate in redox reaction without additional redox reagent, which has the characteristics of mild reaction conditions and good atom economy. This method meets the requirements of green chemistry and sustainable development. With the in-depth study on the mechanism of electrochemical synthesis and the standardization of reaction equipment, this method has become a powerful tool for functionalization of quinoxalineones. The recent advances in the electrochemical C(3)-H functionalization of quinoxaline-2(1H)-one are summarized. The reaction transformation conditions and mechanisms are systematically discussed, and the challenges and future directions of this field are included.