Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode
Tianhong Teng, Ronggui Lin, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang, Heguang Huang
Abstract
, a relatively high fluorescence signal (near infrared second (NIR II)) in PDX tumors can be obtained, which can be precisely imaging-guide local photothermal-chemotherapy upon the 808 nm laser irradiation in vivo. Importantly, the synergy therapeutic efficiency in PDAC is enhanced by the photothermal effect reduction of the number of CAFs, which is confirmed viaα-SMA and vimentin immunofluorescence analysis. This combined therapeutic strategy may provide a new sight for PDAC therapy.
Topics & Concepts
Stromal cellPancreatic cancerAugmentChemotherapyPhotothermal therapyCancer researchChemistryCancerOncologyMedicineInternal medicineMaterials scienceNanotechnologyLinguisticsPhilosophyNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesExtracellular vesicles in disease