Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking
Andrea R. Shiakolas, Kevin J. Kramer, Nicole V. Johnson, Steven C. Wall, Naveenchandra Suryadevara, Daniel Wrapp, Sivakumar Periasamy, Kelsey A. Pilewski, Nagarajan Raju, Rachel S. Nargi, Rachel E. Sutton, Lauren Walker, Ian Setliff, James E. Crowe, Alexander Bukreyev, Robert H. Carnahan, Jason S. McLellan, Ivelin S. Georgiev
Topics & Concepts
Monoclonal antibodyAntibodyVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ReceptorAngiotensin-converting enzyme 2BiologyBlocking (statistics)CoronavirusAntigenCoronavirus disease 2019 (COVID-19)Computational biologyImmunologyMedicineGeneticsDiseaseComputer sciencePathologyInfectious disease (medical specialty)Computer networkSARS-CoV-2 and COVID-19 ResearchCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies Research