A polymeric IDO inhibitor based on poly(ethylene glycol)-<i>b</i>-poly(<scp>l</scp>-tyrosine-<i>co</i>-1-methyl-<scp>d</scp>-tryptophan) enables facile trident cancer immunotherapy
Yuanyuan Liu, Jiguo Xie, Xiaofei Zhao, Yueyue Zhang, Zhiyuan Zhong, Chao Deng
Abstract
T cells, matured dendritic cells (mDCs), and cytokines (IFN-γ, TNF-α), as well as reduced regulatory T cells and downregulated PD-L1 expression at tumor sites, generating immune cascade reactions and a distinct improvement of the tumor microenvironment (TME), leading to significant tumor suppression and survival prolongation. The polymeric IDO inhibitor provides a facile strategy for the co-delivery of chemotherapeutics and inhibitors for efficient and safe combination cancer immunotherapy.
Topics & Concepts
ChemistryTumor microenvironmentCancer immunotherapyImmunotherapyCancer cellCancer researchImmune systemMolecular biologyBiochemistryCancerBiologyImmunologyGeneticsHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationCancer Immunotherapy and Biomarkers