7-nm Mn<sub>0.5</sub> Zn<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub> superparamagnetic iron oxide nanoparticle (SPION): a high-performance theranostic for MRI and hyperthermia applications
Joo Young Lee, Yang Na, C. Na, Pyung Won Im, Hyung Woo Park, Min Gyu Kim, Yona Kim, J.H. You, Dong Su Kang, Hyo Eun Moon, Hye Ran Park, Min Gyu Kim, Pilhan Kim, Sung‐Hye Park, Hye Won Youn, Young‐Don Son, Yasushi Takemura, Chang W. Song, Daishun Ling, Yuanzhe Piao, Sun Ha Paek
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are promising contrast agents for imaging-guided cancer therapies.However, challenges such as the requirement for a high alternating magnetic field (AMF), dosage limitations, and suboptimal imaging contrast have hindered their practical applications.Methods: First, the optimal doping ratio of Mn and Zn in MnxZn1-xFe2O4 nanoparticles synthesized using a modified high-temperature thermal decomposition method (mHTTD) was determined.Then, the magnetic and physical properties of the optimal 7-nm Mn0.5Zn0.5Fe2O4SPIONs were systematically and comprehensively characterized via hysteresis measurements, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray absorption fine structure (XAFS) spectroscopy, and X-ray absorption near edge structure (XANES) spectroscopy.Next, the stability, biosafety, biocompatibility, and theranostic Ivyspring