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The Alzheimer’s disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states

Dalya R. Soond, Jiahong Sun, Rita Cacace, Angie Yee, Chaitanya Wagh, Anna Rychkova, Mariah Dunlap, Daniel R. Gulbranson, Adiljan Ibrahim, Xiaoting Wang, Rebecca Y. Wang, Alice Buonfiglioli, Muhammad Alhawagri, Phil Kong, Marina K. Roell, Wei-Hsien Ho, Belvin Gong, Heidi Denton, Giacomo Muscarnera, Tim Meese, Malak El-Khatib, Daniel P. Bermingham, Elias Kahn, Francesca Cignarella, Hervé Rhinn, Zia Khan, Tina Schwabe, Karpagam Srinivisan, Ananya Mitra, Lot D. de Witte, Peter Heutink, Renzo Mancuso, Ilaria Tassi, Julia Kuhn, Hua Long, Sara Kenkare-Mitra, Arnon Rosenthal

2025Neuron5 citationsDOI

Topics & Concepts

TREM2MicrogliaTransmembrane proteinBiologyReceptorMyeloid cellsGeneFunction (biology)DiseaseCell biologyAmyloid (mycology)NeuroscienceImmunologyAntibodyHEK 293 cellsMyeloidMacrophageGeneticsDownregulation and upregulationCell typeImmune systemCellPhagocytosisAlzheimer's diseaseSignal transductionPhenotypeNeurodegenerationABCA1Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsInflammation biomarkers and pathways
The Alzheimer’s disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states | Litcius