Construction of a novel asymmetric imidazole-cored AIE probe for ratiometric imaging of endogenous leucine aminopeptidase
Xueyan Huang, Qian Lei, Shuai Huang, Hongliang Zeng, Bin Feng, Qinghai Zeng, Yibo Hu, Wenbin Zeng
Abstract
We report a rational strategy to deliberately construct the first asymmetric tetraarylimidazole-based AIE probe, integrating AIE behavior in synergy with ESIPT character to image endogenous LAP for the first time. It offered good sensitivity and selectivity, and concomitantly, was applied successfully for real-time tracking of LAP in the cisplatin-induced liver injury zebrafish model.
Topics & Concepts
AminopeptidaseEndogenyImidazoleChemistryLeucineCombinatorial chemistryBiophysicsBiochemistryAmino acidBiologyLuminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionNanoplatforms for cancer theranostics